The Exploding Plastic Inevitable, sometimes simply called Plastic Inevitable or EPI, was a series of multimedia events organized by Andy Warhol between 1966 and 1967, featuring musical performances by The Velvet Underground & Nico, screenings of Warhol's films, and dancing and performances by regulars of Warhol's Factory, especially Mary Woronov and Gerard Malanga. Andy Warhol's Exploding Plastic Inevitable is also the title of a 18 minute film by Ronald Nameth with recordings from one week of performances of the shows which were filmed in Chicago, Illinois in 1966. In December 1966 Warhol included a one-off underground magazine called The Plastic Exploding Inevitable as part of the Aspen Magazine No. 3 package.
The Exploding Plastic Inevitable had its roots in an event staged on January 13, 1966 at a dinner for the New York Society for Clinical Psychiatry. This event, called "Up-Tight", included performances by The Velvet Underground and Nico, along with Malanga and Edie Sedgwick as dancers. Inaugural shows were held at the Dom in New York City in April 1966, advertised in The Village Voice as follows: "The Silver Dream Factory Presents The Exploding Plastic Inevitable with Andy Warhol/The Velvet Underground/and Nico." Shows were also held in The Gymnasium in New York and in various cities throughout the United States.